TEL
03-5712121 ext 56501
Student Affairs
吳宜霖 Yi-Lin Wu
Associate Professor
Tel | 03-5712121 #56575
Office | SCBII R517
Email | yilin.wu@nycu.edu.tw
Lab Tel | 03-5172121 #56553
Education
2008–2012 Ph.D. in Chemistry, ETH Zurich
2007–2008 M.Sc. in Chemistry, ETH Zurich
2002–2005 B.S. in Chemistry, National Taiwan University
Experiences
Associate Professor, National Yang Ming Chiao Tung University (2025/08–present)
Senior Lecturer in Materials Chemistry, Cardiff University (2024/08–2025/07)
Lecturer in Materials Chemistry, Cardiff University (2019/01–2024/07)
Research Associate Professor, Northwestern University (2017/05–2018/11)
Research Assistant Professor, Northwestern University (2014/05–2017/12)
Postdoctoral Associate, Northwestern University (2012/05–2013/12)
Honors
- 2025 Yushan Young Fellow
- 2022 Fellow of the Higher Education Academy (FHEA)
- 2013 Postdoctoral Professional Development Travel Award
- 2012–2013 Swiss National Science Foundation (SNF) Fellowship for Prospective Researches
- 2009–2011 Scholarship Fund of the Swiss Chemical Industry (SSCI)
- 2008 Novartis M.Sc. Fellowship
- 2007–2008 Scholarship from the Funds Prof. Fritz Medicus, ETH Zürich
- 2003–2005 President’s Award, National Taiwan University
- 2005 Dean’s Award of College of Science, National Taiwan University
- 2004 Microelectronics Corporation (UMC) Scholarship
Publication
Publications
- Huang, Y.; Wu, C.; Lu, A.; Wang, J.; Liang, J.; Sun, H.; Yang, L.; Duan, S.; Berezin, A. A.; Wu, C.; Zhang, B.; Wu, Y.-L.; Tsai, Y.-H. “A Single Bioorthogonal Reaction for Multiplex Cell Surface Protein Labeling” J. Am. Chem. Soc. 2025, 147, 1612–1623.
- Chen, J; Dai, G.; Duan, S.; Huang, Y.; Wu, Y.-L.; Xie, Z.; Tsai, Y.-H. “Selective Protein Degradation through Tetrazine Ligation of Genetically Incorporated Unnatural Amino Acids” Chem. Asian J. 2024, 19, e202400824.
- Williams, T. L.; Taily, I. M.; Hatton, L.; Berezin, A. A.; Wu, Y.-L.; Moliner, V.; Świderek, K.; Tsai, Y.-H.; Luk, L. Y. P. “Secondary Amine Catalysis in Enzyme Design: Broadening Protein Template Diversity through Genetic Code Expansion” Angew. Chem. Int. Ed. 2024, 63, e202403098.
- Wu, Y.-Y.; Wu, Y.-L.; Lin, C.-L.; Chen, H.-C.; Chuang, Y.-Y.; Chen, C.-H.; Chou, C.-M. “Butterfly-Shaped Dibenz[a,j]anthracenes: Synthesis and Photophysical Properties” Org. Lett. 2023, 25, 7763–7768.
- Wright, A. I.; Kariuki, B. M.; Wu, Y.-L. “Synthesis, Solid-state Structure, and Electrochemical Properties of Thienodipyrimidine-2,4,5,7-tetra(thi)ones” Arkivoc 2023, 202311998.
* Dedicated to Professor Tien-Yau Luh on the occasion of his 76th birthday. - Wu, Y.-L.; Wright, A. I. “Why Does Thionating a Carbonyl Molecule Make It a Better Electron Acceptor?” Phys. Chem. Chem. Phys. 2023, 25, 1342–1348.
- Zhou, L.; He, R.; Qin, Y.; Wu, Y.-L.; Jiang, L.; Zhou, D.-D.; Zhang, L. “Multiple C–H⋯Anion and N–H⋯Anion Hydrogen Bond Directed Two-Dimensional Crystalline Nanosheets with Precise Distance Control of Surface Charges for Enhanced DNA Capture” Soft Matter. 2021, 17, 9125–9130.
- Wright, A. I.; Kariuki, B. M.; Wu, Y.-L. “Triplet-Forming Thionated Donor-Acceptor Chromophores for Electrochemically Amphoteric Photosensitization” Eur. J. Org. Chem. 2021, 4647–4652.
* This article also appears in François Diederich Tribute. - Zhou, J.; Stojanović, L.; Berezin, A. A.; Battisti, T.; Gill, A.; Kariuki, B. M.; Bonifazi, D.; Crespo-Otero, R.; Wasielewski, M. R.; Wu, Y.-L. “Organic Room-temperature Phosphorescence from Halogen-bonded Organic Frameworks: Hidden Electronic Effects in Rigidified Chromophores” Chem. Sci. 2021, 12, 767–773.
- del Prado, A.; González-Rodríguez, D.; Wu, Y.-L. “Functional Systems Derived from Nucleobase Self-assembly” ChemistryOpen 2020, 9, 409–430.
* Top Cited Article 2020–2021. - Galstyan, A; Maurya, Y. K.; Zhylitskaya, H.; Bae, Y.; J.; Wu, Y.-L.; Wasielewski, M. R.; Lis, T.; Dobrindt, U; Stępień, M. “π-Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation” Chem. Eur. J. 2020, 26, 8262–8266.
- Bae, Y. J.; Christensen, J. A.; Kang, G.; Malliakas, C. D.; Zhou, J.; Nelson, J. N.; Young, R. M.; Wu, Y.-L.; Van Duyne, R. P.; Schatz, G. C.; Wasielewski, M. R. “Design Principles for Efficient Singlet Fission in Anthracene-Based Organic Semiconductors” SPIE 11084, Physical Chemistry of Semiconductor Materials and Interfaces XVIII, 2019, DOI: 10.1117/12.2527346.
- Bae, Y. J.; Krzyaniak, M. D.; Majewski, M. B.; Desroches, M.; Morin, J. F.; Wu, Y.-L.; Wasielewski, M. R. “Competition between Singlet Fission and Spin-Orbit-Induced Intersystem Crossing in Anthanthrene and Anthanthrone Derivatives” ChemPlusChem 2019, 84, 1432–1438.
- Phelan, B. T.; Zhang, J.; Huang, G. J.; Wu, Y.-L.; Zarea, M.; Young, R. M.; Wasielewski, M. R. “Quantum Coherence Enhances Electron Transfer Rates to Two Equivalent Electron Acceptors” J. Am. Chem. Soc. 2019, 141, 12236–12239.
- Bae, Y. J.; Christensen, J. A.; Kang, G.; Zhou, J.; Young, R. M.; Wu, Y.-L.; Van Duyne, R. P.; Schatz, G. C.; Wasielewski, M. R. “Substituent Effects on Energetics and Crystal Morphology Modulate Singlet Fission in 9,10-Bis(Phenylethynyl)Anthracenes” J. Chem. Phys. 2019, 151, 044501.
- Mandal, A.; Schultz, J. D.; Wu, Y.-L.; Coleman, A. F.; Young, R. M.; Wasielewski, M. R. “Transient Two-Dimensional Electronic Spectroscopy: Coherent Dynamics at Arbitrary Times Along the Reaction Coordinate” J. Phys. Chem. Lett. 2019, 10, 3509–3515.
- Bae, Y. J.; Kang, G.; Malliakas, C. D.; Nelson, J. N.; Zhou, J.; Young, R. M.; Wu, Y.-L.; Van Duyne, R. P.; Schatz, G. C.; Wasielewski, M. R. “Singlet Fission in 9,10-Bis(Phenylethynyl)Anthracene Thin Films” J. Am. Chem. Soc. 2018, 140, 15140–15144.
- Gregolinska, H.; Majewski, M.; Chmielewski, P. J.; Gregolinski, J.; Chien, A.; Zhou, J.; Wu, Y.-L.; Bae, Y. J.; Wasielewski, M. R.; Zimmerman, P. M.; Stepien, M. “Fully Conjugated [4]Chrysaorene. Redox-Coupled Anion Binding in a Tetraradicaloid Macrocycle” J. Am. Chem. Soc. 2018, 140, 14474–14480.
- Wu, Y.-L.; Bobbitt, N. S.; Logsdon, J. L.; Powers-Riggs, N. E.; Nelson, J. N.; Liu, X.; Wang, T. C.; Snurr, R. Q.; Hupp, J. T.; Farha, O. K.; Hersam, M. C.; Wasielewski, M. R. “Tunable Crystallinity and Charge Transfer in 2-Dimensional G-Quadruplex Organic Frameworks” Angew. Chem. Int. Ed. 2018, 57, 3985–3989.
- Goswami, S.; Nelson, J. N.; Islamoglu, ; Wu, Y.-L.; Farha, O. K.; Wasielewski, M. R. “Photoexcited Naphthalene Diimide Radical Anion Linking the Nodes of a Metal–Organic Framework: A Heterogeneous Super-reductant” Chem. Mater. 2018, 30, 2488–2492.
- Mauck, C. M.; Bae Y. J.; Chen, M.; Powers-Riggs, N. E.; Wu, Y.-L.; Wasielewski, M. R. “Charge Transfer Character in a Covalent Diketopyrrolopyrrole Dimer: Implications for Singlet Fission” ChemPhotoChem 2018, 2, 223–233.
- Brown, K. E.; Singh, A. P. N.; Wu, Y.-L.; Ma, L.; Mishra, A. K.; Phelan, B. T.; Young, R. M.; Lewis, F. D.; Wasielewski, M. R. “Fluorescent Excimers and Exciplexes of the Purine Base Derivative 8-Phenylethynylguanine in DNA Hairpins” Faraday Discuss. 2017, 207, 217–232.
- Margulies, E. A.; Kerisit, N.; Gawel, P.; Mauck, C. M.; Ma, L.; Miller, C. E.; Young, R. M.; Trapp, N.; Wu, Y.-L.; Diederich, F.; Wasielewski, M. R. “Substituent Effects on Singlet Exciton Fission in Polycrystalline Thin Films of Cyano-Substituted Diaryltetracenes” J. Phys. Chem. C 2017, 121, 21262–21271.
- Brown, K. E.; Singh, A. P. N.; Wu, Y.-L.; Mishra, A. K.; Zhou, J.; Lewis, F. D.; Young, R. M.; Wasielewski, M. R. “Tracking Hole Transport in DNA Hairpins Using a Phenylethynylguanine Nucleobase” J. Am. Chem. Soc. 2017, 139, 12084–12092.
- Mauck, C. M.; Hartnett, P. E.; Wu, Y.-L.; Miller, C. E.; Marks, T. J.; Wasielewski, M. R. “Singlet Fission within Diketopyrrolopyrrole Nanoparticles in Water” Chem. Mater. 2017, 26, 6810–6817.
- Goswami, S.; Miller, C. E.; Logsdon, J. L.; Buru, C. T.; Wu, Y.-L.; Bowman, D. N.; Islamoglu, T.; Asiri, A. M.; Cramer, C. J.; Wasielewski, M. R.; Hupp, J. T.; Farha, O. K. “Atomistic Approach toward Selective Photocatalytic Oxidation of a Mustard-Gas Simulant: A Case Study with Heavy-Chalcogen-Containing PCN-57 Analogues” ACS Appl. Mater. Interfaces 2017, 9, 19535–19540.
- Šolomek, T.; Powers-Riggs, N. E.; Wu, Y.-L.; Young, R. M.; Krzyaniak, M. D.; Horwitz, N. E.; Wasielewski, M. R. “Electron Hopping and Charge Separation within a Naphthalene-1,4:5,8-bis(dicarboximide) Chiral Covalent Organic Cage” J. Am. Chem. Soc. 2017, 139, 3348–3351.
- Mazza, M. M. A.; Yamazaki, S.; Mai, D. X.; Padgaonkar, S.; Peurifoy, S.; Goncalves, A.; Wu, Y.-L.; Hu, Q.; Scott; A. M. “Photoinduced Charge Recombination in Dipolar D-A-A Photonic Liquid Crystal Polymorphs” Phys. Chem. Chem. Phys. 2017, 19, 4588–4596.
- Wu, Y.-L.; Horwitz, N. E.; Chen, K.-S.; Gomez-Gualdron, D. A.; Luu, N. S.; Ma, L.; Wang, T. C.; Hersam, M. C.; Hupp, J. T.; Farha, O. K.; Snurr, R. Q; Wasielewski, M. R. “G-quadruplex Organic Frameworks” Nat. Chem. 2017, 9, 466–472.
- Hartnett, P. E.; Mauck, C. M.; Harris, M. A.; Young, R. M.; Wu, Y.-L.; Marks, T. J.; Wasielewski, M. R. “Influence of Anion Delocalization on Electron Transfer in a Covalent Porphyrin Donor–Perylenediimide Dimer Acceptor System” J. Am. Chem. Soc. 2017, 139, 749–756.
- Hartnett, P. E.; Margulies, E. A.; Mauck, C. M.; Miller, S. A.; Wu, Y.; Wu, Y.-L.; Marks, T. J.; Wasielewski, M. R. “Effects of Crystal Morphology on Singlet Exciton Fission in Diketopyrrolopyrrole Thin Films” J. Phys. Chem. B. 2016, 120, 1357–1366.
- Huang, G.-J.; Harris, M. A.; Krzyaniak, M. D.; Margulies, E. A.; Dyar, S. M.; Lindquist, R. J.; Wu, Y.; Roznyatovskiy, V. V.; Wu, Y.-L.; Young, R. M.; Wasielewski, M. R. “Photoinduced Charge and Energy Transfer Within meta– and para-Linked Chlorophyll a–Perylene-3,4:9,10-bis(dicarboximide) Donor-Acceptor Dyads” J. Phys. Chem. B. 2016, 120, 756–765.
- Margulies, E. A.; Wu, Y. L.; Gawel, P.; Miller, S. A.; Shoer, L. E.; Schaller, R. D.; Diederich, F.; Wasielewski, M. R. “Sub-Picosecond Singlet Exciton Fission in Cyano-Substituted Diaryltetracenes” Angew. Chem. Int. Ed. 2015, 54, 8679–8683.
- Wu, Y.; Shi, R.; Wu, Y.-L.; Holcroft, J. M.; Liu, Z.; Frasconi, M.; Wasielewski, E. R.; Li, H.; Stoddart, J. F. “Complexation of Polyoxometalates with Cyclodextrins” J. Am. Chem. Soc. 2015, 137, 4111–4118.
- Gawel, P.; Wu, Y.-L.; Finke, A. D.; Trapp, N.; Zalibera, M.; Boudon, C.; Gisselbrecht, J.-P.; Schweizer, W. B.; Gescheidt, G.; Diederich, F. “Push–Pull Buta-1,2,3-trienes: Exceptionally Low Rotational Barriers of Cumulenic C=C Bonds and Their Proacetylenic Reactivity” Chem. Eur. J. 2015, 21, 6215–6225.
- Wu, Y.-L.; Brown K. E.; Gardner, D. M.; Dyar, S. M.; Wasielewski, M. R. “Photoinduced Hole Injection into a Self-assembled π-Extended G-quadruplex” J. Am. Chem. Soc. 2015, 137, 3981–3990.
* Highlighted in JACS Spotlights: J. Am. Chem. Soc. 2015, 137, 3995. - Lefler, K. M.; Kim, C. H.; Wu, Y.-L.; Wasielewski, M. R. “Self-assembly of supramolecular light-harvesting arrays from symmetric perylene-3,4-dicarboximide trefoils” J. Phys. Chem. Lett. 2014, 5, 1608–1615.
- Wu, Y.-L.; Brown, K. E.; Wasielewski, M. R. “Extending Photoinduced Charge Separation Lifetimes by Using Supramolecular Design: Guanine–Perylenediimide G-quadruplex” J. Am. Chem. Soc. 2013, 135, 13322–13325.
* Highlighted in JACS Spotlights: J. Am. Chem. Soc. 2013, 135, 13611. - Wu, Y.-L.; Stuparu, M. C.; Boudon, C.; Gisselbrecht, J.-P.; Schweizer, W. B.; Baldridge, K.; Siegel, J. S.; Diederich, F. “Structural, Optical, and Electrochemical Properties of Three-dimensional Push–Pull Corannulenic Chormophores” J. Org. Chem. 2012, 77, 11014–11026.
- Wu, Y.-L.; Ferroni, F.; Pieraccini, S.; Schweizer, W. B.; Frank, B. B.; Spada G. P.; Diederich F. “1,2-Di(phenylethynyl)ethenes with Axially Chiral, 2,2′-Bridged 1,1′-Binaphthyl Substituents: Potent Cholesteric Liquid-Crystal Inducers” Org. Biomol. Chem. 2012, 10, 8016–8026.
- Wu, Y.-L.; Tancini, F.; Schweizer, W. B.; Paunescu, D.; Boudon, C.; Gisselbrecht, J.-P.; Jarowski, P. D.; Dalcanale, E.; Diederich, F. “Proacetylenic Reactivity of a Push–Pull Buta-1,2,3-triene: New Chromophores and Supramolecular Systems” Chem. Asian J. 2012, 7, 1185–1190.
- Tancini, F.; Wu, Y.-L.; Schweizer, W. B.; Gisselbrecht, J.-P.; Boudon, C.; Jarowski, P. D.; Beels, M. T.; Biaggio, I.; Diederich, F. “1,1-Dicyano-4-[4-(diethylamino)phenyl]buta-1,3-dienes: Structure–Property Relationships.” J. Org. Chem. 2012, 2756–2765.
- Breiten, B.; Wu, Y.-L.; Jarowski, P. D.; Gisselbrecht, J.-P.; Boudon, C.; Griesser, M.; Onitsh, C.; Gescheidt, G.; Schweizer, W. B.; Langer, N.; Lennartz, C; Diederich F. “Donor-substituted Octacyano[4]dendralenes: a New Class of Cyano-rich Nonplanar Organic Acceptors” Chem. Sci. 2011, 2, 88–93.
- Wu, Y.-L.; Bureš, F.; Jarowski, P. D.; Schweizer, W. B.; Gisselbrecht, J.-P.; Boudon, C.; Diederich F. “Proaromaticity: Organic Charge-transfer Chromophores with Small HOMO–LUMO Gaps” Chem. Eur. J. 2010, 16, 9592–9605.
* Highlighted in Synfacts 2010, 1242. - Šišak, D.; McCusker, L. B.; Buckl, A.; Wuitschik, G.; Wu, Y.-L.; Schweizer, W. B.; Dunitz, J. D. “The Search for Tricyanomethane (Cyanoform)” Chem. Eur. J. 2010, 16, 7224–7230.
*Referenced in the article of cyanoform in Wikipedia: http://en.wikipedia.org/wiki/Cyanoform - Wu, Y.-L.; Jarowski, P. D.; Schweizer, W. B.; Diederich F. “Mechanistic Investigation of the Dipolar [2+2] Cycloaddition-cycloreversion Reaction Between 4-(N,N-Dimethylamino)phenylacetylene and Arylated 1,1-Dicyanovinyl Derivatives to Form Intramolecular Charge-transfer Chromophores” Chem. Eur. J. 2010, 16, 202–211.
- Lin, H.-C.; Hsu, J.-H.; Lee, C.-K.; Tai, O. Y.-H.; Wang, C.-H.; Chou, C.-M.; Chen, K.-Y.; Wu, Y.-L.; Luh, T.-Y. “Observing Second-order Nonlinear Optical Properties by Symmetry Breaking in Centrosymmetric Furan-containing Oligoaryl Cyclophandienes” Chem. Eur. J. 2009, 15, 13201–13209.
- Chou, C.-M.; Biju, A. T.; Wang, H.-W.; Wu, Y.-L.; Zhang, G.-F.; Chen, C.-H.; Yang, K.-W.; Lim, T.-S.; Lee, S.-L.; Huang, M.-J.; Chen, C.-h.; Tsai, P.-Y.; Lin, K.-C.; Huang, S.-L.; Luh, T.-Y. “Polymeric Ladderphanes” J. Am. Chem. Soc. 2009, 131, 12579–12858.
- Jarowski, P. D.; Wu, Y.-L.; Boudon, C.; Gisselbrecht, J.-P.; Gross, M.; Schweizer, W. B.; Diederich F. “New Donor–Acceptor Chromophores by Formal [2+2] Cycloaddition of Donor-substituted Alkynes to Dicyanovinyl Derivatives” Org. Biomol. Chem. 2009, 7, 1312–1322.
- Jarowski, P. D.; Wu, Y.-L.; Schweizer, W. B.; Diederich F. “1,2,3-Triazoles as Conjugative π-Linkers in Push–Pull Chromophores: Importance of Substituent Positioning on Intramolecular Charge-transfer” Org. Lett. 2008, 10, 3347–3350.
- Lin, C.-L.; Wu, Y.-L.; Chen, C.-L.; Chou, C.-M.; Luh, T.-Y. “Sequential Electrochemical Oxidation of Alternating Benzene-furan Oligomers” J. Org. Chem. 2007, 72, 8531–853.
