TEL
03-5712121 ext 56501
Student Affairs
許馨云 Hsin-Yun Hsu
Professor
- Tel | +886-3-5712121 #56556
- Office | TKB R615B
- Email: hyhsu99@nycu.edu.tw
- Lab tel | TKB R619
- Lab tel |+ 886-3-5712121 #56556
Education
2004 – 2008 Ph.D. (Dr. rer. nat) Biochemie, University of Tübingen, Germany
2001 – 2003 M.S. Biomedical Engineering, National Taiwan University, Taiwan
1997 – 2001 B.S. Agricultural Chemistry, National Taiwan University, Taiwan
Experiences
2021 – date Professor, National Yang Ming Chiao-Tung University, Taiwan
2020 – 2021 Professor, National Chiao-Tung University, Taiwan
2015 – 2020 Associate Professor, National Chiao-Tung University, Taiwan
2010 – 2015 Assistant Professor, National Chiao-Tung University, Taiwan
2008 – 2010 Postdoctoral Fellow, Kazusa DNA Research Institute, Japan
Honors
- 2017 Outstanding Young Scholar Research Award, National Chiao-Tung University
- 2017 Lectureship Award of Chemical Society of Japan, 97th CSJ Annual Meeting
- 2004-2008 DAAD Research Fellowship (Forschungsstipendien fuer Doktoranden und Nachwuchswissenschaftler), Germany
- 2006 Award for the 56th Lindau Nobel Laureate Meeting – dedicated in Chemistry
Publication
Journal Papers
- HJ Lin, YQ Yang, WT Chang, HY Hsu*, I Liau*. (2025) Development of a Zebrafish Platform for Modeling Reperfusion Injury in Neonatal Hypoxic–Ischemic Encephalopathy: Validation with S-Nitrosoglutathione. Biochemical and Biophysical Research Communications, 784, 152613 (SCI)
- K Awasthi, WC Huang, CY Wei, HY Hsu, N Ohta. (2025) Unveiling the susceptibility of nanosecond pulsed electric field on intracellular function in breast cancerous and normal cells using fluorescence imaging. Biosensors and Bioelectronics 272, 117129 (SCI)
- TI Lin, PY Hsieh, HJ Lin, CK Chiang, JJC Sheu, WT Chang, I Liau*, HY Hsu*. (2025) Soy Protein-Cultured Mesenchymal Stem Cell-Secreted Extracellular Vesicles Target the Neurovascular Unit: Insights from a Zebrafish Brain Injury Model. ACS Biomaterials Science & Engineering 11 (3), 1432-1444 (SCI)
- Yu-Hsuan Chang, I-Chia Huang, Shao-Yung Huang, Yen-Ku Wu*, Hsin-Yun Hsu* (2023, Aug). Tandem photo-crosslinking/sol–gel reaction for the green synthesis of morphology-alterable, redox-responsive silica particles. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 670, 131525. (SCI).
- Kamlesh Awasthi, Tsai-En Wu, Hsin-Yun Hsu, Nobuhiro Ohta (2023, Jun). Application of Nanosecond Pulsed Electric Field and Autofluorescence Lifetime Microscopy of FAD in Lung Cells. The Journal of Physical Chemistry B, 127, 5566–5575. (SCI).
- Awasthi K., Li S.-P., Zhu C.-Y., Hsu H.-Y., Ohta N. (2022, Dec). Fluorescence microscopic approach for detection of two different modes of breast cancer cell death induced by nanosecond pulsed electric field. Sensors and Actuators, B: Chemical, https://doi.org/10.1016/j.snb.2022.133199. (SCI).
- Kamlesh Awasthi, Feng-Lin Chang, Tsai-En Wu, Hsin-Yun Hsu, Nobuhiro Ohta (2022, Oct). Modulation of calcium signaling by nanosecond electric pulses and cell death through apoptosis in A549 lung cancerous cells. Sensors and Actuators, B: Chemical, 369, 132348. (SCI).
- Awasthi, F.-L. Changa, H.-Y. Hsu, N. Ohta (2021, Nov). Cancer specific apoptosis induced by electric field: A possible key mechanism in cell-competition and photodynamic action. Sensors and Actuators B: Chemical, 347, 130635. (SCI).
- J. Klionsky , A. K. Abdel-Aziz, S. Abdelfatah , M. Abdellatif , A. Abdoli , S. Abel , H. Abeliovich , M. H Abildgaard… H.Y. Hsu,…and C.-K.Tong, et al. (2021, Feb). Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition). Autophagy, 17, 1-382. (SCI).
- Tzu-Yin Chen, Wan-Jung Cheng, Jia-Cherng Horng, Hsin-Yun Hsu* (2020, Mar). Artificial peptide-controlled protein release of Zn2+-triggered, self-assembled histidine-tagged protein microparticle. Colloids and Surfaces B: Biointerfaces, 187, 110644. (SCI).
- Yu-Hsuan Chang, Wan-Ling Peng, I-Chia Chen, Hsin-Yun Hsu and Yen-Ku Wu (2020, Mar). Palladium-catalyzed α-arylation of indolin-3-ones. Chemical Communications, 56, 4660-4663. (SCI).
- Awasthi K, Chang FL, Hsieh PY, Hsu HY, Ohta N (2020, Feb). Characterization of endogenous fluorescence in nonsmall lung cancerous cells: A comparison with nonmalignant lung normal cells. Journal of Biophotonics, 13: e201960210. (SCI).
- Karunya Albert, Pei-Ying Hsieh, Tsai-Hsuan Chen, Chia-Hung Hou, Hsin-Yun HSU* (2020, Feb). Diatom-assisted biomicroreactor targeting the complete removal of perfluorinated compounds. Journal of Hazardous Materials, 384, 121491. (SCI).
- Wei-Ming Tu, Xin-Chun Huang, Yen-Ling Chen, Yun-Ling Luo, Ian Liau, Hsin-Yun HSU* (2020, Jan). Longitudinal and quantitative assessment platform for concurrent analysis of anti-tumor efficacy and cardiotoxicity of nano-formulated medication in vivo. Analytica Chimica Acta, 1095, 129-137. (SCI).
- Tsai MZ, Hsiung CT, Chen Y, Huang CS, Hsu HY and Hsieh PY (2018, Jan). Real-time CRP detection from whole blood using micropost-embedded microfluidic chip incorporated with label-free biosensor. Analyst, 143, 503-510. (SCI).
- Yu G; Hung C-Y; Hsu H-Y (2018, Jan). An Agricultural Waste Based Composite to Replace or Reduce the Use of Plastics. International Journal of Environmental Science and Development, 9(7), 167-172.
- Albert K, Huang XC, Hsu HY* (2017, Nov). Bio-templated silica composites for next-generation biomedical applications. Advances in Colloid and Interface Science, 249, 272-289. (SCI).
- Chen HY, Albert K, Wen CC, Hsieh PY, Chen SY, Huang NC, Lo SC, Chen JK, Hsu HY* (2017, Jan). Multifunctional Silver Nanocluster-Hybrid Oligonucleotide Vehicle for Cell Imaging and MicroRNA-Targeted Gene Silencing. Colloids and Surfaces B: Biointerfaces, 152, 423–431. (SCI).
- Albert K, Hsu HY* (2016, Nov). Carbon-Based Materials for Photo-Triggered Theranostic Applications. Molecules, 21(11), E1585. (SCI).
- Chen TH, Hsu HY, Wu SP (2016, Oct). The detection of multiple illicit street drugs in liquid samples by direct analysis in real time (DART) coupled to Q-orbitrap tandem mass spectrometry. Forensic Science International, 267, 1-6. (SCI).
- Huang XC, Inoue-Aono Y, Moriyasu Y, Hsieh PY, Tu WM, Hsiao SC, Jane WN, Hsu HY* (2016, Sep). Plant Cell Wall-Penetrable, Redox-Responsive Silica Nanoprobe for the Imaging of Starvation-Induced Vesicle Trafficking. Analytical Chemistry, 88 (20), 10231–10236. (SCI).
- Okano K, Hsu HY, Li YK, Masuhara H. (2016, Sep). In situ patterning and controlling living cells by utilizing femtosecond laser. Journal of Photochemistry and Photobiology C: Photochemistry Reviews, 28, 1-28 . (SCI).
- Gayam SR, Venkatesan P, Sung YM, Sung SY, Hu SH, Hsu HY, Wu SP (2016, May). NAD(P)H: quinone oxidoreductase 1 (NQO1) enzyme responsive nanocarrier based on mesoporous silica nanoparticles for tumor targeted drug delivery in vitro and in vivo. Nanoscale, 8, 12307-12317. (SCI).
- Huang CH, Tsai MS, Chien KL, Chang WT, Wang TD, Chen SC, Ma HM, Hsu HY*, Chen WJ* (2016, May). Predicting the outcomes for out-of-hospital cardiac arrest patients using multiple biomarkers and suspension microarray assays. Scientific Reports, 6, 27187. (SCI).
- Lin HA, Hsu HY, Chang CW, Huang CS (2016, May). Compact spectrometer system based on a gradient grating period guided-mode resonance filter. Optics Express, 24, 10972 . (SCI).
- Chen YC, Nien CY, Albert K., Wen CC, Hsieh YZ, HSU HY* (2016, Apr). Pseudo-Multicolor Carbon Dots Emission and the Dilution-Induced Reversible Fluorescence Shift. RSC Advances, 6, 44024-44028. (SCI).
- Tu YK, Tsai MZ, Lee IC, Hsu HY, Huang CS (2016, Apr). Integration of a Guided-Mode Resonance Filter with Microposts for In-Cell Protein Detection. Analyst, 141, 4189-4195. (SCI).
- Huang CY, Tsai PY, Lee IC, Hsu HY, Huang HY, Fan SK, Yao DJ, Liu CH, Hsu W* (2016, Jan). A highly efficient bead extraction technique with low bead number for digital microfluidic immunoassay. Biomicrofluidics, 10, 011901. (SCI).
- Luo YL, Huang XC, Tu WM, Hsu HY* (2016, Jan). Differential in situ sensing of extra- and intracellular glutathione by a novel redox-responsive silica matrix-Au nanoprobe. Analytica Chimica Acta, 902,196-204. (SCI).
- Hsu JF, Hsieh PY, Hsu HY, Shigeto S* (2015, Dec). When cells divide: Label-free multimodal spectral imaging for exploratory molecular investigation of living cells during cytokinesis . Scientific Reports, 5,17541. (SCI).
- Sung YM, Gayam S; Hsieh PY, Hsu HY, Diau E, Wu SP* (2015, Nov). Quinone-Modified Mn-Doped ZnS Quantum Dots for Room-Temperature Phosphorescence Sensing of Human Cancer Cells that Overexpress NQO1. ACS Applied Materials & Interfaces, 7, 25961-25969. (SCI).
- Ding TS, Huang XC, Luo YL, Hsu HY* (2015, Jul). In vitro investigation of methylene blue-bearing, electrostatically assembled aptamer-silica nanocomposites as potential photodynamic therapeutics. Colloids Surf B Biointerfaces, 135, 217-224 . (SCI).
- Hsieh CJ, Chen YC, Hsieh PY, Liu SR, Wu SP, Hsieh YZ, Hsu HY* (2015, May). Graphene oxide-based nanocarrier combined with a pH-sensitive tracer: a vehicle for concurrent pH sensing and pH-responsive oligonucleotide delivery . ACS Applied Materials & Interfaces, 7, 11467-11475. (SCI).
- Huang XC, Wu LB, Hsu JF, Shigeto S, Hsu HY* (2015, May). Biothiol-triggered, Self-disassembled Silica Nanobeads for Intracellular Drug Delivery. Acta Biomaterialia, 23, 263-270. (SCI).
- Huang CY, Shih PH, Tsai PY, Lee IC, Hsu HY, Huang HY, Fan SK and Hsu W (2015, Feb). AMPFLUID: aggregation magnified post-assay fluorescence for ultrasensitive immunodetection on digital microfluidics. Proceedings of the IEEE, 103, 225-235. (SCI).
- Liu TK, Hsieh PY, Zhuang YD, Hsia CY, Huang CL, Lai HP, Lin HS, Chen IC, Hsu HY*, Tan KT* (2014, Aug). A Rapid SNAP-tag Fluorogenic Probe Based on Environment-Sensitive Fluorophore for No-Wash Live Cell Imaging. ACS Chemical Biology, 9, 2359-2365. (SCI).
- Chen YC, Wen CC, Liau I, Hsieh YZ and Hsu HY* (2014, Apr). Oligonucleotides as ‘bio-solvent’ for in situ extraction and functionalisation of carbon nanoparticles. Mater. Chem. B, 2, 4100-4107. (SCI).
- Chen YC, Huang XC, Luo YL, Chang YC, Hsieh YZ and Hsu HY* (2013, Aug). Non-metallic nanomaterials in cancertheranostics: a review of silica- and carbon-based drug delivery systems . Technol. Adv. Mater., 14, 044407 . (SCI).
- André MC, Gille C, Glemser P, Woiterski J, Hsu HY, Spring B, Keppeler H, Kramer BW, Handgretinger R, Poets CF, Lauber K, Orlikowsky TW (2012, Jun). Bacterial reprogramming of PBMCs impairs monocyte phagocytosis and modulates adaptive T cell responses. J Leukoc Biol, 91, 977-89. (SCI).
- Hsu HY (2011, Aug). Suspension Microarrays in Biosensing Applications. Chemistry, 69(3): 255-263. (其它).
- Schneiderhan-Marra N, Sauer G, Kazmaier C, Hsu HY, Koretz K, Deissler H, Joos TO (2010, Aug). Multiplexed Immunoassays for the analysis of breast cancer biopsies. Anal Bioanal Chem, 397(8):3329-38. (SCI).
- Punyadeera C, Schneider EM, Schaffer D, Hsu HY, Joos TO, Kriebel F, Weiss M, Verhaegh W (2010, Jul). A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsis severity. J Emerg Trauma Shock, 3(1), 26-35. (Scopus).
- Hsu HY*, Joos TO, Koga H (2009, Dec). Multiplex microsphere-based flow cytometric platforms for protein analysis and their application in clinical proteomics – from assays to results. Electrophoresis, 30, 4008-4019. (SCI).
- Hsu HY, Wittemann S, Schneider EM, Joos TO* (2008, Oct). Suspension microarrays to identify the response patterns in hyperinflammatory diseases. Eng. Phys., 30, 976-983. (SCI).
- Woehrle T, Du W, Goetz A, Hsu HY, Joos TO, Weiss M, Bauer U, Brueckner UB, Schneider EM* (2008, Mar). Pathogen specific cytokine release reveals an effect of TLR2 Arg753Gln during Candida sepsis in humans. Cytokine, 41, 322-9. (SCI).
- Pelttari K, Lorenz H, Boeuf S, Templin MF, Bischel O, Goetzke K, Hsu HY, Steck E, Richter W.* (2008, Feb). Secretion of MMP3 by expanded articular chondrocytes predicts ectopic cartilage formation capacity in vivo. Arthritis & Rheumatism., 58, 467-74. (SCI).
- Mueller W, Schneider M, Joos T, Hsu HY, Stratz T. (2007, Oct). Subgroups of fibromyalgia.. Schmerz, 21, 424–429. (SCI).
- Huang YY*, Hsu HY, Huang CJ (2007, Jan). A protein detection technique by using surface plasmon resonance (SPR) with rolling circle amplification (RCA) and nanogold-modified tags.. Bioelectron., 22, 980-985. (SCI).
- Kriebel F, Wittemann S, Hsu HY, Joos T, Weiss M, Schneider EM.* (2006, Dec). Caspase-3 activation, Bcl-2 contents, and soluble FAS-ligand are not related to the inflammatory marker profile in patients with sepsis and septic shock.. Ann N Y Acad Sci., 1090, 168-176. (SCI).
- H-Y Hsu; Y-Y Huang (2004, Jul). RCA combined nanoparticle-based optical detection technique for protein microarray: a novel approach. Biosensors and Bioelectronics, 20(1), 123-126. (SCI).
Book Chapters
- Huang XC, Luo YL and Hsu HY*. Redox-triggered, biocompatible, inorganic nanoplatforms for cancer theranostics. Biological and Pharmaceutical Applications of Nanomaterials (ISBN: 9781482250169). CRC Press. Jul, 2015.
- Yu XB, Schneiderhan-Marra N, Hsu HY, Bachmann J, Joos TO. Protein microarrays – effective tools for the study of inflammatory diseases. Reverse Chemical Genetics. Methods Mol Biol.. Sep, 2009: 577, 199-214.
- Hsu HY, Wittemann S, Joos TO. Clinical proteomics: Methods and Protocols: Miniaturized multiplex immunoassays. Methods Mol Biol.. Feb, 2008: 428, 247-61.
- H-Y Hsu; H-Y Yeh; S-Y Yeh; Y-Y Huang. Enzymatic amplification combined with nanoparticles-based detection for Microarray. Functional Micro- and Nanosystems (ISBN: 978-3-642-05999-5). Springer-Verlag Berlin Heidelberg . Jan, 2004: pp 55-58.
Research Highlights
