孫仲銘 教授

Prof. Sun’s laboratory developed a new multidisciplinary synthetic approach comprising polymer support synthesis, microwave assisted synthesis and multicomponent condensation to facilitate synthesis of scaffold-directed library with a set of advantages like rapid process, simple purification and structural diversity in one shot. Microwave irradiation greatly accelerates the rate of all reactions while polymer support facilitates purifications by simple precipitation technique. This strategy dramatically increases efficiency of overall multistep synthesis of G9a (an unique target for cancer stem cell) inhibitors.